EP300(S1834) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityEP300(S1834)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman
Isotypen/a
FormatProtein A purified
Size0.05 mL, 0.2 mL
Concentrationn/a
ApplicationsWestern Blot (WB), ELISA (EIA)
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DescriptionThis antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1807-1841 amino acids from human. Functions as histone acetyltransferase and regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac). Also functions as acetyltransferase for nonhistone
Immunogenn/a
Other Names[Purified Rabbit (Pab); Histone acetyltransferase p300; p300 HAT; 2.3.1.48; E1A-associated protein p300; EP300; P300]
Gene, Accession #[EP300], Gene ID: 2033, NCBI: NP_001420.2, UniProt: Q09472
Catalog #MBS9231237
Price$165, $370
Order / More InfoEP300(S1834) Antibody from MYBIOSOURCE INC.
Product Specific ReferencesEckner R.,et al.Genes Dev. 8:869-884(1994). Dunham I.,et al.Nature 402:489-495(1999). Mural R.J.,et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Chaffanet M.,et al.Genes Chromosomes Cancer 28:138-144(2000). Lundblad J.R.,et al.Nature 374:85-88(1995).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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