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Antigenic Specificity | TAB1 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody detects endogenous levels TAB1(N-terminus) and does not cross-react with related proteins. UniPort Summary Function: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Entrez Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative |
Immunogen | Immunogen: Purified recombinant human TAB1(N-terminus) protein fragments expressed in E Coli. |
Other Names | [3?-Tab1; MAP3K7IP1], [TAB1; TAB1; 3'-Tab1; MAP3K7IP1; MAP3K7IP1; TAK1-binding protein 1] |
Gene, Accession # | [TAB1], Gene ID: 10454, NCBI: NP_006107.1, UniProt: Q15750 |
Catalog # | MBS857839 |
Price | $300 |
Order / More Info | TAB1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |