Phospho-MDM2-S260 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-MDM2-S260 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S450 of human MDM2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [HDMX; hdm2; ACTFS; MGC5370; MGC71221] |
| Gene, Accession # | [MDM2-S260], Gene ID: 4193, NCBI: NP_001138811.1, UniProt: Q00987 |
| Catalog # | MBS8527447 |
| Price | $310 |
| Order / More Info | Phospho-MDM2-S260 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Haupt, Y. et al. (1997) Nature 387, 296-299. 2. Mayo, L.D. and Donner, D.B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603. 3. Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981. 4. Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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