p53 (DO-1) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | p53 (DO-1) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | n/a |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | 0.100 mg/ml |
| Applications | Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Detects p53 of Human origin. The p53 tumor suppressor gene encodes a transcription factor that contributes to several cellular activities that include apoptosis, transient growth arrest, and sustained growth arrest or senescence (1). Mutations within the p53 gene are found in about half of all human cancers (2). In cells that are functioning normally the MDM2 protein binds to p53 and maintains p53 at low levels by increasing its susceptibility to proteolysis by the 26S proteosome (3). A cell that undergoes stress loses the ability of MDM2 to bind to p53 and as a result p53 levels increase which then leads to cell cycle arrest or apoptosis (3&4). p53 induced cell cycle arrest or apoptosis can be achieved through transcriptional regulation of |
| Immunogen | Origin: p53 (DO-1) is a mouse monoclonal IgG2a derived by fusion of X63Ag 8.653 mouse myeloma cells with spleen cells from a BALB/C mouse immunized with recombinant wild type p53 protein. The epitope maps to amino acids 11-25 of wt and mutant p53 of human origin. |
| Other Names | [P53; Cellular tumor antigen p53; cellular tumor antigen p53; antigen NY-CO-13; mutant tumor protein 53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53], [TP53; TP53; P53; BCC7; LFS1; TRP53; P53] |
| Gene, Accession # | [p53], Gene ID: 7157, NCBI: BAC16799.1, UniProt: P04637 |
| Catalog # | MBS440089 |
| Price | $340 |
| Order / More Info | p53 (DO-1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Bargonetti J, Manfredi JJ. 2002. Multiple Roles of the tumor suppressor p53. Curr Opin Oncol 14(1):86-912. Vousden KH. 2002. Activation of the p53 tumor suppressor protein. Biochim Biophys Acta 1602(1):47-593. Momand J, Wu HH, Dasgupta G. 2000. MDM2?master regulator of the p53 tumor suppressor protein. Gene 242(1-2):15-294. Alarcon-Vargas D, Ronai Z. 2002. p53-MDM2?the affair that never ends. Carcinogenesis 23(4):541-5475. Gong B, Almasan A. 1999. Differential upregulation of p53-responsive genes by genotoxic stress in hematopoietic cells containing wild-type and mutant p53. Gene Expr 8(4):197-2066. Kaelin WG Jr. 1999. The emerging p53 gene family. J Natl Cancer Inst 91(7):594-598. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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