Phospho-MET-Y1234 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | Phospho-MET-Y1234 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Met, a high affinity tyrosine kinase receptor for hepatocyte growth factor (HGF, also known as scatter factor) is a disulfide-linked heterodimer made of 45 kDa alpha-and 145 kDa beta-subunits (1, 2). The alpha-subunit and the amino-terminal region of the beta-subunit form the extracellular domain. The remainder of the beta-chain spans the plasma membrane and contains a cytoplasmic region with tyrosine kinase activity. Interaction of Met with HGF results in autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl, and PI3 kinase (3). These fundamental events are important for all of the biological functions involving Met kinase activity. The addition of a phosphate at cytoplasmic |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y1234 of human MET Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [HGFR; AUTS9; RCCP2; c-Met] |
| Gene, Accession # | [MET-Y1234], Gene ID: 4233, NCBI: NP_000236.2, UniProt: P08581 |
| Catalog # | MBS8527449 |
| Price | $310 |
| Order / More Info | Phospho-MET-Y1234 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Cooper, C.S. et al. (1984) Nature 311, 29-33. 2. Bottaro, D.P. et al. (1991) Science 251, 802-4. 3. Bardelli, A. et al. (1997) Oncogene 15, 3103-11. 4. Taher, T.E. et al. (2002) J Immunol 169, 3793-800. 5. Schaeper, U. et al. (2000) J Cell Biol 149, 1419-32. 6. Eder, J.P. et al. (2009) Clin Cancer Res 15, 2207-14. 7. Sattler, M. and Salgia, R. (2009) Update Cancer Ther 3, 109-118. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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