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Antigenic Specificity | Cyclosome 1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total Cyclosome 1 protein. Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.Joergensen P.M., Gene 262:51-59(2001).Ota T., Nat. Genet. 36:40-45(2004).Kraft C., EMBO J. 22:6598-6609(2003). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human Cyclosome 1. |
Other Names | [ANAPC1; ANC1; Anaphase promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator] |
Gene, Accession # | Gene ID: 64682, NCBI: NP_073153.1, UniProt: Q9H1A4 |
Catalog # | MBS9404473 |
Price | $200, $255 |
Order / More Info | Cyclosome 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |