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Antigenic Specificity | Chk2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Chk2 Antibody detects endogenous levels of total Chk2. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphoryla |
Immunogen | Immunogen: A synthesized peptide derived from human Chk2. Fragment: Fab fragment Predicted Cross Reactivity: : Pig (100%), Bovine (91%), Horse (100%), Sheep (91%), Dog (91%) |
Other Names | [Chk2 - C-terminal; CDS 1; Cds1; Cds1 homolog; Checkpoint kinase 2; Checkpoint like protein CHK2; CHEK 2; Chek2; Chk 2; CHK2 checkpoint homolog (S. pombe); CHK2 checkpoint homolog; CHK2_HUMAN; hCds1; HuCds 1; LFS 2; LFS2; PP1425; RAD 53; RAD53; Rad53 homolog; Serine/threonine protein kinase Chk2; Serine/threonine-protein kinase Chk2;] |
Gene, Accession # | [Chk2], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
Catalog # | MBS9610342 |
Price | $240, $280 |
Order / More Info | Chk2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |