Phospho-IKKb (Y199) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Phospho-IKKb (Y199) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.38 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This IKKb Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y199 of human IKKb. NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the inhibitory I-kappa-B proteins by kinases (IKKa or IKKb) leads to the dissociation of the inhibitor/NF-kappa-B complex and marks the inhibitors for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding |
| Immunogen | n/a |
| Other Names | [Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; IKBKB; IKKB] |
| Gene, Accession # | [IKBKB], Gene ID: 3551, NCBI: NP_001177649.1, UniProt: O14920 |
| Catalog # | MBS9206431 |
| Price | $165, $370 |
| Order / More Info | Phospho-IKKb (Y199) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Tomasoni, S., et al., Transplantation 79(9):1056-1061 (2005). Lappas, M., et al., Endocrinology 146(3):1491-1497 (2005). Carcamo, J.M., et al., Mol. Cell. Biol. 24(15):6645-6652 (2004). May, M.J., et al., J. Biol. Chem. 279(44):45528-45539 (2004). Ea, C.K., et al., Proc. Natl. Acad. Sci. U.S.A. 101(43):15318-15323 (2004). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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