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Antigenic Specificity | TNK1 |
Clone | [1B5G3; 3F11H6] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TNK1: tyrosine kinase, non-receptor, 1. TNK1 is a nonreceptor tyrosine kinase(NRPTK). These kinases, like members of the SRC (MIM 190090) and JAK (see MIM 147795) families, mediate intracellular signaling downstream of receptor activation.Tnk1 is a ubiquitously expressed 47-kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity. |
Immunogen | Immunogen: Purified recombinant fragment of TNK1 (aa451-560) expressed in E. Coli. |
Other Names | [MGC46193; TNK1] |
Gene, Accession # | [TNK1], Gene ID: 8711, NCBI: AAH35782.1, UniProt: Q13470 |
Catalog # | MBS8538430 |
Price | $280 |
Order / More Info | TNK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |