Edit |   |
---|---|
Antigenic Specificity | SCK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Sck Polyclonal Antibody detects endogenous levels of Sck protein. Src homology 2 (SH2) domains bind specifically to tyrosine-phosphorylated proteins that temporally participate in signal transduction events. Shc-like protein (Sck) is a neuronal adaptor protein that contains an N-terminal PTB (phosphotyrosine binding) domain, a collagen homology (CH) domain, and a conserved C-terminal SH2 domain. Human Sck transcripts are present at high levels in liver, pancreas, prostate and ovary. In vascular endothelial cells, Sck participates in VEGF-induced signal transduction. Treatment of human umbilical vein endothelial (HUVEC) cells with VEGF induces recruitment of Sck to tyrosine-1175 of the kinase insert domain-containing receptor (K |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human Sck at AA rangle: 230-310 |
Other Names | [Rabbit Sck; SHC2; SCK; SHCB; SHC-transforming protein 2; Protein Sck; SHC-transforming protein B; Src homology 2 domain-containing-transforming protein C2; SH2 domain protein C2] |
Gene, Accession # | [SCK], Gene ID: 25759, NCBI: NP_036567.2, UniProt: P98077 |
Catalog # | MBS9705078 |
Price | $130, $220, $325 |
Order / More Info | SCK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |