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Antigenic Specificity | Initiator Caspases Antibody Sampler Kit |
Clone | n/a |
Host Species | n/a |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 1 kit |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background: Apoptosis is a regulated physiological process leading to cell death. Caspases, a family of cysteine acid proteases, are central regulators of apoptosis. Initiator caspases (including 2, 8, 9, 10 and 12) are closely coupled to proapoptotic signals, which include FasL, TNF-alpha, and DNA damage. Once activated, these caspases cleave and activate downstream effector caspases (including 3, 6 and 7), which in turn cleave cytoskeletal and nuclear proteins such as PARP, alpha-fodrin, DFF and lamin A; inducing apoptosis. Formation of a death-inducing signaling complex (DISC) around the receptors for death factors, including FasL and TNF-alpha, is essential for receptor-mediated apoptosis. Upon ligand activation, Fas and TNF-R1 associat |
Immunogen | n/a |
Other Names | [initiator caspase; initiator caspase; initiator caspase] |
Gene, Accession # | Gene ID: 693266, NCBI: NP_001038154.1 |
Catalog # | MBS2550009 |
Price | $295 |
Order / More Info | Initiator Caspases Antibody Sampler Kit Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |