TNF Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityTNF
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formatantigen affinity purified
Size0.06 mL, 0.12 mL, 0.2 mL
Concentration1mg/mL
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionTNF-alpha, the prototypical member of the TNF protein superfamily, is a homotrimeric type-II membrane protein (1, 2). Membrane-bound TNF-alpha is cleaved by the metalloprotease TACE/ADAM17 to generate a soluble homotrimer (2). Both membrane and soluble forms of TNF-alpha are biologically active. TNF-alpha is produced by a variety of immune cells including T cells, B cells, NK cells, and macrophages (1). Cellular response to TNF-alpha is mediated through interaction with receptors TNF-R1 and TNF-R2 and results in activation of pathways that favor both cell survival and apoptosis depending on the cell type and biological context. Activation of kinase pathways (including JNK, Erk (p44/42), p38 MAPK, and NF-kappaB) promotes the survival of cell
ImmunogenImmunogen: C term -peptide of human TNF Observed Molecular Weight: 26kDa
Other Names[TNF; TNFSF2; DIF; Tumor necrosis factor; TNF a; TNF alpha]
Gene, Accession #[TNF], Gene ID: 7124
Catalog #MBS2519797
Price$150, $225, $360
Order / More InfoTNF Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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