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Antigenic Specificity | Human CD286 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | IgG concentration 1.0mg/ml |
Applications | Immunohistology Frozen, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit anti Human CD286 antibody recognizes human CD286, also known as Toll-like receptor 6 (TLR6), a member of the evolutionarily conserved toll-like receptor family (TLRs) and close homologue of CD281 (TLR1), that is expressed by monocytes, CD11c+ immature dendritic cells and endothelial cells of skin microvessels. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. CD286 acts via a cytokine signaling pathway to induce the activation of NF-kappaB, through the formation of dimers with CD282 (TLR2) which coordinate macrophage activation by Gram-positive bacteria and zymosan. CD286/CD282 dimers are also involved in apoptotic responses |
Immunogen | Immunogen: A synthetic peptide corresponding to a 13 amino acid sequence located near the centre of human CD286. Buffer Solution: Phosphate buffered saline Antiserum Preparation: Antisera to human CD286 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. Target Species: Human |
Other Names | [toll-like receptor 6; Toll-like receptor 6; toll-like receptor 6; toll-like receptor 6; CD_antigen: CD286], [TLR6; TLR6; CD286] |
Gene, Accession # | [CD286], Gene ID: 10333, NCBI: NP_006059.2, UniProt: Q9Y2C9 |
Catalog # | MBS221330 |
Price | $375 |
Order / More Info | Human CD286 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |