AP2M1 Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | AP2M1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The AP-2 coat assembly protein complex is an important component of clathrin-coated pits involved in receptor-mediated endocytosis at the plasma membrane (1-3). Each AP-2 heterotetramer is composed of alpha, beta, mu, and sigma protein subunits. The 50 kDa mu subunit (AP-2mu, AP2M1) is located at the core of the AP-2 complex and mediates interaction between the cargo protein and the clathrin-coated pit (1-4). The carboxy-terminal AP2M1 region recognizes the tyrosine-based, endocytotic sorting motif YXX phi found in cargo proteins and helps to bring the cargo protein to the clathrin-coated pit. Non-canonical, tyrosine-based endocytotic sorting signals can also promote interaction between cargo proteins and AP2M1 (5, 6). AP2M1 plays an essent |
| Immunogen | Immunogen: Recombinant protein of human AP2M1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [AP50; CLAPM1; mu2] |
| Gene, Accession # | [AP2M1], Gene ID: 1173, NCBI: NP_001020376.1, UniProt: Q96CW1 |
| Catalog # | MBS8500082 |
| Price | $310 |
| Order / More Info | AP2M1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kirchhausen, T. (2002) Cell 109, 413-6. 2. Ohno, H. et al. (1995) Science 269, 1872-5. 3. Traub, L.M. (2003) J Cell Biol 163, 203-8. 4. Boll, W. et al. (1996) EMBO J 15, 5789-95. 5. Royle, S.J. et al. (2002) J Biol Chem 277, 35378-85. 6. Royle, S.J. et al. (2005) J Cell Sci 118, 3073-80. 7. Chin, Y.R. and Horwitz, M.S. (2005) J Virol 79, 13606-17. 8. Wernick, N.L. et al. (2005) J Biol Chem 280, 7309-16. 9. Johannessen, L.E. et al. (2006) Mol Cell Biol 26, 389-401. 10. Uekita, T. et al. (2001) J Cell Biol 155, 1345-56. 11. Chen, Z. et al. (2006) Am J Respir Cell Mol Biol 35, 127-32. 12. Honing, S. et al. (2005) Mol Cell 18, 519-31. 13. Olusanya, O. et al. (2001) Curr Biol 11, 896-900. 14. Conner, S.D. and Schmid, S.L. (2002) J Cell Biol 156, 921-9. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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