Human CD41 (gpIIb) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD41 (gpIIb) |
| Clone | [RKCD41] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Protein G purified |
| Size | 0.5 mg, 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The platelet glycoprotein IIb (αIIb; CD41) constitutes the alpha subunit of a highly expressed platelet surface integrin protein. CD41 is a protein composed of two subunits that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Damage to blood vessels results in the release of a variety of intracellular mediators as well as initiation of the hemostatic cascade that in combination activate CD41/CD61 to bind to a variety of proteins including fibrinogen, fibronectin, von Willebrand factor and vitronectin.CD41/CD61 was once considered to be a platelet specific-receptor complex and has long been used as a phenotypic marker for the megakaryocyte- platelet lineage. |
| Immunogen | Host Note: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with recombinant E. coli-derived Human SCF. |
| Other Names | [Mouse Human CD41; cd41; cd-41;; mab; integrin; gpiibB], [ITGA2B; GP2B; ITGAB; GPIIb] |
| Gene, Accession # | [CD41], Gene ID: 3674, NCBI: NP_000410.2, UniProt: P08514 |
| Catalog # | MBS550102 |
| Price | $480, $775 |
| Order / More Info | Human CD41 (gpIIb) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • CD41 progenitors are critical for the engraftment of hematopoietic cells derived from embryonic stem cells.Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 2548. • CD41 cmyb precursors colonize the zebrafish pronephros by a novel migration route to initiate adult hematopoiesis.Development, May 2008; 135: 1853 - 1862. • modulation of murine embryonic stem cell-derived CD41 c-kit hematopoietic progenitors by ectopic expression of cdx genes.Blood, May 2008; 111: 4944 - 4953. • analysis of thrombocyte development in CD41-gfp transgenic zebrafish.Blood, Dec 2005; 106: 3803 - 3810. • CD41 and vascular endothelial (ve) -cadherin cells: two developmental origins of hematopoietic cell lineages that show different hematogenic potentials.Blood (ASH Annual Meeting Abstracts), Nov 2005; 106: 3612. |
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MYBIOSOURCE INC.
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