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Antigenic Specificity | CD34 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | mouse, human, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD34 is a heavily glycosylated type I transmembrane molecule, that can be phoshorylated by a variety of kinases including Protein kinase C and Tyrosine kinases. CD34 antigen is expressed on small vessel endothelial cells and tumors of epithelial origin. CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. So CD34 is considered to be ideal marker for identifying and quantifying hematopoietic progenitor stem cells. With interaction with C |
Immunogen | Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human GSK3beta around the phosphorylation site of serine 9 (T-T-SP-F-A). Preservative: 0.05% Sodium Azide. Cellular Localization: Cell Membrane |
Other Names | [hematopoietic progenitor cell antigen CD34 isoform a; Hematopoietic progenitor cell antigen CD34; hematopoietic progenitor cell antigen CD34; CD34 molecule; CD_antigen: CD34], [CD34; CD34] |
Gene, Accession # | [CD34], Gene ID: 947, NCBI: NP_001020280.1, UniProt: P28906 |
Catalog # | MBS857333 |
Price | $280 |
Order / More Info | CD34 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Freund D., Wiebe G.J., Ehninger G., Corbeil D.; Sequence analysis of the human CD34 antigen.; Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases. 2. The MGC Project Team; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).; Genome Res. 14:2121-2127(2004). 3. Sutherland D.R., Watt S.M., Dowden G., Karhi K., Baker M.A., Greaves M.F., Smart J.E.; Structural and partial amino acid sequence analysis of the human hemopoietic progenitor cell antigen CD34.; Leukemia 2:793-803(1988). |