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Antigenic Specificity | HIRA (Phospho Thr555) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-HIRA (T555) Polyclonal Antibody detects endogenous levels of HIRA protein only when phosphorylated at T555. HIRA (histone cell cycle regulator) encodes a histone chaperone that preferentially places the variant histone H3. in nucleosomes. Orthologs of HIRA in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryo |
Immunogen | Immunogen: Synthesized peptide derived from human HIRA around the phosphorylation site of T555 |
Other Names | [Rabbit HIRA (phospho Thr555); HIRA; DGCR1; HIR; TUPLE1; Protein HIRA; TUP1-like enhancer of split protein 1] |
Gene, Accession # | [HIRA], Gene ID: 7290, NCBI: NP_003316.3, UniProt: P54198 |
Catalog # | MBS9707088 |
Price | $130, $220, $325 |
Order / More Info | HIRA (Phospho Thr555) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |