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Antigenic Specificity | Phospho-ACK1 (Y826) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ACK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y826 of human ACK1. ACK1 is a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. |
Immunogen | n/a |
Other Names | [Activated CDC42 kinase 1; ACK-1; Tyrosine kinase non-receptor protein 2; TNK2; ACK1] |
Gene, Accession # | [TNK2], Gene ID: 10188, NCBI: NP_001010938.1, UniProt: Q07912 |
Catalog # | MBS9211014 |
Price | $165, $370 |
Order / More Info | Phospho-ACK1 (Y826) Antibody from MYBIOSOURCE INC. |
Product Specific References | Guo A, et al. (2008) A 105, 692-7 Rikova K, et al. (2007) Cell 131, 1190-203 Huang PH, et al. (2007) Proc Natl Acad Sci U S A 104, 12867-72 Wolf-Yadlin A, Hautaniemi S, Lauffenburger DA, White FM (2007) Proc Natl Acad Sci U S A 104, 5860-5 Goss VL, et al. (2006) Blood 107, 4888-97 Wolf-Yadlin A, et al. (2006) Mol Syst Biol 2, 54 Rush J, et al. (2005) Nat Biotechnol 23, 94-101 |