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Antigenic Specificity | SDCBP |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety o |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human SDCBP (NP 001007068.1). |
Other Names | [ST1; MDA9; SYCL; MDA-9; TACIP18] |
Gene, Accession # | [SDCBP], Gene ID: 6386, NCBI: O00560.1, UniProt: O00560 |
Catalog # | MBS8545529 |
Price | $280 |
Order / More Info | SDCBP Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |