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Antigenic Specificity | IFN-alpha, Mouse |
Clone | F18 |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.5 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Functional Studies (FS), Immuno Assay (IA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The monoclonal antibody F18 recognizes and neutralizes both natural and recombinant mouse alpha Interferon (IFN-alpha). IFN-alpha is a cytokine that belongs to the type I interferons (IFN-I). IFN-alpha is secreted by many cell types including lymphocytes (NK cells, B-cells and T-cells), macrophages, fibroblasts, endothelial cells, osteoblasts, microglia and others. Interferons stimulate both macrophages and NK cells to elicit an anti-viral response, and are also active against tumors. Although all cells can produce IFN-I, plasmacytoid dendritic cells (pDCs) produce 1, 000-fold higher levels than other cell types, and are responsible for systemic IFN-I responses to many viruses. They are coined as the natural IFN-producing cells. However, un |
Immunogen | n/a |
Other Names | [IFN-alpha], [IFNA1; IFNA1; IFL; IFN; IFNA@; IFNA13; IFN-ALPHA; IFN-alphaD; IFN-alpha-1/13; LeIF D] |
Gene, Accession # | [IFN-alpha], Gene ID: 3439, NCBI: NP_076918.1, UniProt: P01562 |
Catalog # | MBS584698 |
Price | $1080 |
Order / More Info | IFN-alpha, Mouse Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Dalod, M et al; Interferon alpha/beta and interleukin 12 responses to viral infections: pathways regulating dendritic cell cytokine expression in vivo. J Exp Med 2002, 195: 517 2. Diebold, S et al; Viral infection switches nonplasmacytoid dendritic cells into high interferon producers. Nature 2003, 424: 324 3. Joshi, V et al; A role for Stat1 in the regulation of lipopolysaccharide-induced Interleukin-1beta expression. J Interferon Cytokine Res 2006, 26: 739. 4. Wilkstrom, M et al; A Chemokine-Like Viral Protein Enhances Alpha Interferon Production by Plasmacytoid Dendritic Cells but Delays CD8 T Cell Activation and Impairs Viral Clearance. J Virol 2013, 87:7911 |