c-Cbl (C-terminal Region) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | c-Cbl (C-terminal Region) |
| Clone | monoclonal |
| Host Species | Mouse |
| Reactive Species | human, rat, mouse |
| Isotype | IgG1 |
| Format | Protein A purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | ELISA, Western Blot |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects a 120 kDa* protein in human Jurkat cells. c-Cbl proto-oncogene is a ubiquitously expressed cytoplasmic adaptor protein that is especially predominant in hematopoietic cells. c-Cbl possesses a highly conserved amino-terminal phosphotyrosine binding domain and a C3HC4 RING finger motif. c-Cbl is rapidly tyrosine phosphorylated in response to stimulation of a variety of cell-surface receptors and becomes associated with a number of intracellular signaling molecules such as protein tyrosine kinases, phosphatidylinositol 3 kinase (PI3K), Crk and 14-3-3 proteins. In human cancer tissues, c-Cbl is frequently tyrosine phosphorylated in a tumor-specific manner. Src-family kinases primarily phosphorylate c- Cbl at Tyr-700, Tyr-73 |
| Immunogen | Immunogen: Clone (M159) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues in the C-terminal region of c-Cbl. This sequence is highly conserved in rat and mouse c-Cbl. |
| Other Names | [c-Cbl (C-terminal Region); E3 ubiquitin-protein ligase CBL; RING finger protein 55], [CBL; CBL; CBL2; NSLL; C-CBL; RNF55; CBL2; RNF55] |
| Gene, Accession # | Gene ID: 867, UniProt: P22681 |
| Catalog # | MBS470005 |
| Price | $325 |
| Order / More Info | c-Cbl (C-terminal Region) Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Blake, T. J. et al. (1991) Oncogene 6:653.• Donovan, J.A., et al. (1994) J. Biol. Chem. 269:37.• Rivero-Lezcano, O.M. et al. (1994) J. Biol. Chem. 269:26.• Christine, B. F. et al. (2001) Nat. Rev. Mol. Cell Biol. 2:294. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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