CD73, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD73, Human |
| Clone | 4G4 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | F, Flow Cytometry (FC/FACS), FS, Immunoflurescence (IF), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody 4G4 recognizes both membrane bound and soluble human CD73, also known as ecto-5-nucleotidase. CD73 is a 70-kDa GPI-anchored cell surface molecule and belongs to the 5-nucleosidase family. CD73 is useful as marker for lymphocyte differentiation. It is abundantly expressed on the vascular endothelium and at a low level on certain subpopulations of human lymphocytes. Like many glycosyl-phosphatidylinositol (GPI)-anchored molecules, it transmits potent activation signals in T cells when ligated by antibodies. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Ecto-5-nucleotidase activity is an important mediator of the antiinflammatory effect by converting extracellular AM |
| Immunogen | Immunogen: Inflamed synovial stroma from rheumatoid arthitis patients |
| Other Names | n/a |
| Gene, Accession # | [CD73] |
| Catalog # | MBS584066 |
| Price | $555 |
| Order / More Info | CD73, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Airas, L et al; Lymphocyte-vascular adhesion protein-2 is a novel 70-kDa molecule involved in lymphocyte adhesion to vascular endothelium. J Immunol 1993, 151: 4228 2. Airas, L et al; CD73 is involved in lymphocyte binding to the endothelium: characterization of lymphocyte-vascular adhesion protein 2 identifies it as CD73. J Exp Med 1995, 182: 1603 3. Airas, L et al; Differential regulation and function of CD73, a glycosyl-phosphatidylinositol-linked 70-kD adhesion molecule, on lymphocytes and endothelial cells. J Cell Biol 1997, 136: 421 4. Airas, L et al; CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism. J Immunol 2000, 165: 5411 5. Niemelr, J et al; IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5-nucleotidase) up-regulation. J Immunol 2004, 172: 1646 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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