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Antigenic Specificity | SUPT16H |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein k |
Immunogen | Immunogen: Recombinant human FACT complex subunit SPT16 protein |
Other Names | [FACT complex subunit SPT16; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chroma; SUPT16H; FACT140; FACTP140] |
Gene, Accession # | [SUPT16H], Gene ID: 11198, NCBI: NP_009123.1, UniProt: Q9Y5B9 |
Catalog # | MBS7044150 |
Price | $160, $235 |
Order / More Info | SUPT16H Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |