MLK-3 (Mixed lineage kinase-3) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-MLK-3 (Mixed lineage kinase-3) antibody, protein, ELISA kits.
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| Antigenic Specificity | MLK-3 (Mixed lineage kinase-3) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | purified |
| Size | 0.1 mg |
| Concentration | 1ug/ul |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Mixed lineage kinase-3 (MLK-3) is a 97 kDa serine/threonine kinase with multiple interaction domains, including a Cdc42 binding motif, but unknown function. In support of this role, we demonstrate that MLK-3 can specifically activate the SAPK/JNK and p38/RK pathways, but has no effect on the activation of ERKs. Immunoprecipitated MLK-3 catalyzed the phosphorylation of SEK1 in vitro, and co-transfected MLK-3 induced phosphorylation of SEK1 and MKK3 at sites required for activation, suggesting direct regulation of these protein kinases. Furthermore, interactions between MLK-3 and SEK and MLK-3 and MKK6 were observed in co-precipitation experiments. Finally, kinase-dead mutants of MLK-3 blocked activation of the SAPK pathway by a newly identif |
| Immunogen | Immunogen: Ni-NTA purified recombinant human MLK-3 expressed in E Coli strain M15. |
| Other Names | n/a |
| Gene, Accession # | [MLK 3] |
| Catalog # | MBS418213 |
| Price | $445 |
| Order / More Info | MLK-3 (Mixed lineage kinase-3) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Rana, A. Gallo, K. Godowski, P. Hirai, S., Ohno, S. Zon, L., Kyriakis, J.M. and Avruch, J. The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem. 1996. 271, 19025. |
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MYBIOSOURCE INC.
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