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Antigenic Specificity | PDX1 (N-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse, rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This PDX1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-55 amino acids from the N-terminal region of human PDX1. Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic |
Immunogen | n/a |
Other Names | [Pancreas/duodenum homeobox protein 1; PDX-1; Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1; PDX1; IPF1; STF1] |
Gene, Accession # | [PDX1], Gene ID: 3651, NCBI: NP_000200.1, UniProt: P52945 |
Catalog # | MBS9203180 |
Price | $165, $370 |
Order / More Info | PDX1 (N-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Stoffel M.,et al.Genomics 28:125-126(1995). Inoue H.,et al.Diabetes 45:789-794(1996). Hiroshi I.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases. Marshak S.,et al.Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases. Hara M.,et al.Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases. |