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Antigenic Specificity | ATR (Ab-428) Antiobdy |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total ATR protein. ATR encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcrip |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around aa.426~430 (G-I-S-P-K) derived from Human ATR. |
Other Names | [FRP1; MEC1; SCKL; SCKL1] |
Gene, Accession # | [ATR], Gene ID: 545, NCBI: NP_001175.2, UniProt: Q13535 |
Catalog # | MBS9407994 |
Price | $200, $255 |
Order / More Info | ATR (Ab-428) Antiobdy Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |