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Antigenic Specificity | DNAJC2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA s |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human DNAJC2 (NP 055192.1). |
Other Names | [ZRF1; ZUO1; MPP11; MPHOSPH11] |
Gene, Accession # | [DNAJC2], Gene ID: 27000, NCBI: Q99543.4, UniProt: Q99543 |
Catalog # | MBS8545417 |
Price | $280 |
Order / More Info | DNAJC2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |