Edit |   |
---|---|
Antigenic Specificity | NTF3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total NTF3 antibody. NT-3 is a member of the structurally related neurotrophin family of proteins, which includes b-NGF, BDNF and NT-4 (1). NT-3 is expressed in a number of cell types including neuronal cells, eosinophils, and melanocytes (1-3). NT-3 is required for the development of peripheral sensory neurons (4). NT-3 is secreted from cells as a precursor protein, which is proteolytically cleaved into the mature form (1). NT-3 signaling is mediated through two distinct receptors, the neurotrophin receptor p75NTR and the Trk tyrosine kinase receptor TrkC. While all neurotrophins bind to the p75NTR receptor, NT-3 preferentially binds to TrkC and, with lesser affinity, TrkB (1). |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human NTF3. |
Other Names | [NTF3; HDNF; MGC129711; NGF-2; NGF2; NT3] |
Gene, Accession # | [NTF3], Gene ID: 4908, NCBI: NP_001096124.1, UniProt: P20783 |
Catalog # | MBS9402409 |
Price | $255 |
Order / More Info | NTF3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |