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Antigenic Specificity | CTSB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cathepsin B (CSTB), part of the papain family of proteases, is a widely expressed lysosomal cysteine endopeptidase (1,2). Like other family members, cathepsin B is produced from a larger precursor form, pro-cathepsin B, which in its glycosylated form runs at approximately 40 kDa on SDS-PAGE, and is then activated by cleavage of a 62-amino acid pro-peptide. High levels of cathepsin B are found in macrophages and osteoclasts, as well as various types of cancer cells, including lung, colon, prostate, breast, and stomach. In addition, expression of cathepsin B has been associated with multiple sclerosis (3), rheumatoid arthritis (4), and pancreatitis (5). While generally localized to lysosomes, in cancer alterations can lead to its secretion (6 |
Immunogen | Immunogen: Recombinant Protein |
Other Names | [CTSB; APPS; CPSB; Cathepsin B], [CTSB; CTSB; APPS; CPSB; CPSB; APPS] |
Gene, Accession # | [CTSB], Gene ID: 1508, NCBI: P07858.3, UniProt: P07858 |
Catalog # | MBS127909 |
Price | $200, $275, $430 |
Order / More Info | CTSB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |