alpha-Actinin 4 (ACTN4) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | alpha-Actinin 4 (ACTN4) |
| Clone | [93] |
| Host Species | Mouse |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for endogenous levels of the ~105 kDa alpha-actinin 4 protein. alpha-actinin-4 is a member of the actinin protein family comprised of an actin-binding domain in the N-terminus, 4 spectrin-like repeats in the central region, and 2 EF-hand motifs in the C-terminus (Honda et al, 1998). alpha-actinin-4 and CLP36 form a complex in normal kidney podocytes.CLP36 is dependent on alpha-actinin-4 for maintenance of its level in podocytes, whereas alpha-actinin-4 is independent of CLP36. alpha-actinin-4 is widely expressed in mammalian tissues and organs, while having a high occurrence of genetic mutations in kidney podocytes (Kos et al, 2003). FSGS, focal segmental glomerulosclerosis, is a rare genetic disease that attacks the k |
| Immunogen | Immunogen Species: Mouse. Immunogen Information: Fusion protein from the central rod domain of alpha-actinin 4. |
| Other Names | [Alpha Actinin 4], [ACTN4; ACTN4; FSGS; FSGS1; ACTININ-4] |
| Gene, Accession # | [ACTN4], Gene ID: 81, NCBI: O43707.2, UniProt: O43707 |
| Catalog # | MBS500081 |
| Price | $360 |
| Order / More Info | alpha-Actinin 4 (ACTN4) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Liu Z, Blattner SM, Yizeng T, Tisherman R, Wang JH, Rastaldi MP, Kretzler M, Wu C. alpha-Actinin-4 and CLP36 Protein Deficiencies Contribute to Podocyte Defects in Multiple Human Glomerulopathies. J Biol Chem 286(35):30795-805 (2011). 2. Honda K, Yamada T, Endo R, ino Y, Gotoh M, Tsuda H, Yamada Y, Chiba H, Hirohashi S. Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol. 140(6): 1383-93 (1998). 3. Kos CH, Le TC, Sinha S, Henderson JM, Kim SH, Sugimoto H, Kalluri R, Gerszten RE, Pollak MR. Mice deficient in alpha-actinin-4 have severe glomerular disease. J Clin Invest 111(11):1683-90 (2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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