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Antigenic Specificity | ILK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total ILK protein. Integrin-linked kinases (ILKs) couple integrins and growth factors to downstream pathways involved in cell survival, cell cycle control, cell-cell adhesion and cell motility (1). ILK functions as a scaffold bridging the extracellular matrix (ECM) and growth factor receptors to the actin cytoskeleton through interactions with integrin, PINCH (which links ILK to the RTKs via Nck2), CH-ILKBP and affixin (1). ILK phosphorylates Akt at Ser473, GSK-3 on Ser9, myosin light chain 2 (MLC2) on Ser18/Thr19, as well as affixin (2-5). These phosphorylation events are key regulatory steps in modulating the activities of the targets. ILK activity is stimulated by PI3 kinase and negatively regulat |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human ILK. |
Other Names | [ILK; DKFZp686F1765; P59; ILK1] |
Gene, Accession # | [ILK], Gene ID: 3611, NCBI: NP_001014794.1, UniProt: Q13418 |
Catalog # | MBS9410411 |
Price | $255 |
Order / More Info | ILK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |