Edit |   |
---|---|
Antigenic Specificity | GRK4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.02 mL, 0.06 mL, 0.12 mL |
Concentration | 1mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |
Immunogen | Immunogen: Recombinant protein of human GRK4 Calculated Molecular Weight: 67kDa |
Other Names | [IT11; GPRK4; GRK4a; GPRK2L] |
Gene, Accession # | [GRK4], Gene ID: 2868, NCBI: NP_005298.2 |
Catalog # | MBS2527406 |
Price | $110, $150, $225 |
Order / More Info | GRK4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |