Alpha Synuclein (pSer129) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Alpha Synuclein (pSer129) |
| Clone | [J18] |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | IgG |
| Format | affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/ml |
| Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein. Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzhe |
| Immunogen | Immunogen: Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys Conjugate: Unconjugated |
| Other Names | [Rabbit Human Alpha Synuclein pSer129 IgG; Alpha Synuclein (pSer129); Phosphorylated alpha synuclein; Phospho alpha Synuclein (S129); Alpha-synuclein (phospho S129); alpha Synuclein (phospho Ser129); alpha-Synuclein Phospho Ser129; phospho-alpha-Synuclein (Ser129); Alpha synuclein; Alpha synuclein phospho Serine 129; Alpha synuclein phospho Ser 129; Alpha synuclein pSerine 129; Alpha synuclein pSer 129; Alpha synuclein phosphoSer 129; Alpha-synuclein; Alpha-synuclein; isoform NACP140; alphaSYN; NACP; Non A beta component of AD amyloid; Non A4 component of amyloid; Non A4 component of amyloid precursor; Non-A beta component of AD amyloid; Non-A-beta component of alzheimers disease amyloid; precursor of; Non-A4 component of amyloid precursor; Non-A4 component of amyloid; precursor of; PARK 1; PARK 4; PARK1; PARK4; Parkinson disease (autosomal dominant; Lewy body) 4; Parkinson disease familial 1; SNCA; alpha (non A4 component of amyloid precursor); SYN; Synuclein alpha; Synuclein alpha 140; Synuclein; alpha (non A4 component of amyloid precursor); SYUA_HUMAN; Alpha Synuclein pSer129] |
| Gene, Accession # | [alphaSYN], Gene ID: 6622, NCBI: NP_000336.1, UniProt: P37840 |
| Catalog # | MBS8005541 |
| Price | $525 |
| Order / More Info | Alpha Synuclein (pSer129) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Genetics Home Reference: SNCA. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Fujiwara H., et al. (2002) Nat Cell Biol. 4(2):160-4. 8. Anderson J.P., et al. (2006) J Biol Chem. 281(40):29739-52. |
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