TSC2 (Center S1385/S1386), 1364-1393 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TSC2 (Center S1385/S1386), 1364-1393 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse, rat) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.3 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This TSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1364-1393 amino acids from the Central region of human TSC2. In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of |
| Immunogen | n/a |
| Other Names | [Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4] |
| Gene, Accession # | [TSC2], Gene ID: 7249, NCBI: NP_000539.2, UniProt: P49815 |
| Catalog # | MBS9214439 |
| Price | $165, $370 |
| Order / More Info | TSC2 (Center S1385/S1386), 1364-1393 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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