Edit |   |
---|---|
Antigenic Specificity | HUWE1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total HUWE1 protein. This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic mental retardation. |
Immunogen | Immunogen: Synthetic peptide of human HUWE1 Immunogen Type: Peptide |
Other Names | [MULE; Ib772; LASU1; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272] |
Gene, Accession # | [HUWE1], Gene ID: 10075, NCBI: NP_113584.3, UniProt: Q7Z6Z7 |
Catalog # | MBS9417380 |
Price | $255 |
Order / More Info | HUWE1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |