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Antigenic Specificity | MAVS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the sa |
Immunogen | Immunogen: Recombinant human Mitochondrial antiviral-signaling protein(1-65aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-70096 / sc-68926 |
Other Names | [MAVS; CARD adapter inducing interferon beta; Cardif; Interferon beta promoter stimulator protein 1; IPS-1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter; VISA; MAVS; IPS1; KIAA1271; VISA], [MAVS; MAVS; IPS1; VISA; IPS-1; CARDIF; IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA] |
Gene, Accession # | [MAVS], Gene ID: 57506, NCBI: NP_001193420.1, UniProt: Q7Z434 |
Catalog # | MBS1499447 |
Price | $120, $160 |
Order / More Info | MAVS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |