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Antigenic Specificity | BTRC |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total BTRC protein. b-transducin repeat-containing protein (b-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1,2). b-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IkBa, b-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Research studies have shown that inhibition of b-TrCP expression has a demonstrated benefi |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human BTRC. |
Other Names | [BETA-TRCP; FBW1A; FBXW1; FBXW1A; FWD1] |
Gene, Accession # | [BTRC], Gene ID: 8945, NCBI: NP_003930.1, UniProt: Q9Y297 |
Catalog # | MBS9403922 |
Price | $255 |
Order / More Info | BTRC Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |