TLR3, Human Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | TLR3, Human |
| Clone | TLR3.7 |
| Host Species | Mouse |
| Reactive Species | human, dog, mouse |
| Isotype | IgG1 |
| Format | unconjugated |
| Size | 0.5 mg |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Formalin/Paraffin, Flow Cytometry (FC/FACS), Functional Studies (FS), Immunofluorescence (IF), Immunoprecipitation (IP) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The monoclonal antibody TLR3.7 recognizes the 116 kDa human Toll-like receptor 3 (TLR3, CD283). Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFkappaBdependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the deve |
| Immunogen | Immunogen: Human Flag-tagged TLR3 stably expressed by Ba/F3 cells |
| Other Names | [CD283; Toll-like receptor 3], [TLR3] |
| Gene, Accession # | [TLR3], NCBI: ADV90560.1 |
| Catalog # | MBS584742 |
| Price | $1215 |
| Order / More Info | TLR3, Human Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Matsumoto, M et al; Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signalling. Biochem Biophys Res Commun 2002, 293: 1364 2. Oshiumi, H et al; TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction. Nat Immunol 2003, 4: 161 3. Matsumoto, M et al; Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 2003, 171: 3154 4. Burgener, I et al; Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol 2008, 124; 184 5. Jorgenson, R et al; Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA. Human Immunology 2005; 66:469 |
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