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Antigenic Specificity | Human WIPI1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays an important role in autophagy and in particular starvation- and calcium-mediated autophagy, as well as in mitophagy. Functions upstream of the ATG12-ATG5-ATG16L1 complex and LC3, and downstream of the ULK1 and PI3-kinase complexes. Involved in xenophagy of Staphylococcus aureus. Invading S.aureus cells become entrapped in autophagosome-like WIPI1 positive vesicles targeted for lysosomal degradation. Plays also a distinct role in controlling the transcription of melanogenic enzymes and melanosome maturation, a process that is distinct from starvation-induced autophagy. May also regulate the trafficking of proteins involved in the mannose-6-phosphate receptor (MPR) recycling pathway. |
Immunogen | Immunogen: Recombinant human WD repeat domain phosphoinositide-interacting protein 1 protein (187-446aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83064 / sc-83063 / sc-292635 |
Other Names | [WIPI-1; Atg18 protein homolog; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WIPI 49 kDa; WIPI1; WIPI49], [WIPI1; WIPI1; ATG18; ATG18A; WIPI49; WIPI49; WIPI-1; WIPI 49 kDa] |
Gene, Accession # | [WIPI1], Gene ID: 55062, NCBI: NP_060453.3, UniProt: Q5MNZ9 |
Catalog # | MBS1499885 |
Price | $120, $160 |
Order / More Info | Human WIPI1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |