Human CCR4 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-Human CCR4 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | Human CCR4 |
| Clone | [KH-4F5] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | Protein G purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC/FACS), CELISA |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: anti-human CCR4. Background: CCR4 (CC chemokine receptor 4) belongs to the rhodopsin family of G-protein-coupled receptors. Chemokine receptors are membrane-bound molecules composed of 7- transmembrane domains and are coupled to G-proteins (1,2). CCR4 binds the chemokines CCL17 (TARC) and CCL22 (MDC) and is highly expressed in most single-positive CD4( ) thymocytes especially in TH2- and regulatory T-cells (3,4). It plays a central role in T cell migration to the thymus, T cell maturation and education. CCR4 is often up-regulated in inflammation and cause conformational changes that trigger intracellular signaling pathways (2,5). |
| Immunogen | Immunogen: Immunogen: peptide |
| Other Names | [CC chemokine receptor 4], [CCR4; CCR4; CKR4; K5-5; CD194; CMKBR4; ChemR13; CC-CKR-4; HGCN:14099; CMKBR4; C-C CKR-4; CC-CKR-4; CCR-4; CCR4] |
| Gene, Accession # | Gene ID: 1233, NCBI: NP_005499.1, UniProt: P51679 |
| Catalog # | MBS468021 |
| Price | $505 |
| Order / More Info | Human CCR4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Andrew DP et al. (2001). C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinalmemory T cells of both Th1 and Th2 potential. J Immunol 166(1): 103-11Murdoch C and Finn A (2000). Chemokine receptors and their role in inflammation and infectious diseases.Blood 95 (10): 3032-3043Imai T et al. (1997). The T cell-directed CC chemokine TARC is a highly specific biological ligand for CCchemokine receptor 4. J Biol Chem 6;272(23):15036-42Imai T et al. (1998). Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor4. J Biol Chem 16;273(3):1764-8Purandare AV and Somerville JE (2006). Antagonists of CCR4 as immunomodulatory agents. Curr TopMed Chem 6(13):1335-44 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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