Presenilin 1 (PSEN1) (C-term), 330-359 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Presenilin 1 (PSEN1) (C-term), 330-359 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse (predicted reactivity: monkey, rat) |
| Isotype | n/a |
| Format | purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 2 |
| Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Presenilin 1 (PSEN1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-359 amino acids from the C-terminal region of human Presenilin 1 (PSEN1). Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that th |
| Immunogen | n/a |
| Other Names | [Presenilin-1; PS-1; 3423-; Protein S182; Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12; PS1-CTF12; PSEN1; AD3; PS1; PSNL1] |
| Gene, Accession # | [PSEN1], Gene ID: 5663, NCBI: NP_000012.1, UniProt: P49768 |
| Catalog # | MBS9204178 |
| Price | $165, $370 |
| Order / More Info | Presenilin 1 (PSEN1) (C-term), 330-359 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Marambaud, P., et al., Cell 114(5):635-645 (2003). Kim, S.H., et al., J. Biol. Chem. 278(36):33992-34002 (2003). Miklossy, J., et al., Neurobiol. Aging 24(5):655-662 (2003). Cai, D., et al., J. Biol. Chem. 278(5):3446-3454 (2003). Godin, C., et al., Neuroreport 14(12):1613-1616 (2003). |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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