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Antigenic Specificity | MLK1 (C-term), 1070-1104 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MLK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1070-1104 amino acids from the C-terminal region of human MLK1. MLK1 is a MLK(MAP3K) type protein kinase. The catalytic domain of mixed-lineage kinases (MLKs) kinases have amino acid sequence similarity to both the tyr-specific and the ser/thr-specific kinase classes. In addition to thee unusual nature of the kinase catalytic domains, MLK1 and MLK2 contain 2 leu/ile-zipper motifs and a basic sequence near their C-termini. MLK1 is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. MLK1 expression has been documented in human epithelial tumor cell lines of colonic, breast and es |
Immunogen | n/a |
Other Names | [Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K9; MLK1; PRKE1] |
Gene, Accession # | [MAP3K9], Gene ID: 4293, NCBI: NP_149132.2, UniProt: P80192 |
Catalog # | MBS9214102 |
Price | $165, $370 |
Order / More Info | MLK1 (C-term), 1070-1104 Antibody from MYBIOSOURCE INC. |
Product Specific References | Durkin, J.T., et al., Biochemistry 43(51):16348-16355 (2004). Gallo, K.A., et al., J. Biol. Chem. 269(21):15092-15100 (1994). Dorow, D.S., et al., Eur. J. Biochem. 213(2):701-710 (1993). |