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Antigenic Specificity | CUL5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total CUL5 protein. Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human CUL5. |
Other Names | [VACM1; VACM-1] |
Gene, Accession # | [CUL5], Gene ID: 8065, NCBI: NP_003469.2, UniProt: Q93034 |
Catalog # | MBS9406263 |
Price | $255 |
Order / More Info | CUL5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |