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Antigenic Specificity | CIS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of CIS. The protein encoded by CISH contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of CISH can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for CISH. CISH (Cytokine Inducible SH2 Containing Protein) is |
Immunogen | Immunogen: Synthesized peptide derived from part region of human CIS protein at amino acid sequence of 30-90 |
Other Names | [Rabbit CIS; Cytokine-inducible SH2-containing protein; CIS; CIS-1; Protein G18; Suppressor of cytokine signaling; SOCS] |
Gene, Accession # | [CIS], Gene ID: 1154, NCBI: Q9NSE2.1, UniProt: Q9NSE2 |
Catalog # | MBS9708743 |
Price | $130, $220, $325 |
Order / More Info | CIS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |