Human Apoptosis-inducing factor 1, mitochondrial Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human Apoptosis-inducing factor 1, mitochondrial |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | biotin conjugate |
| Size | 0.05 mg, 0.1 mg |
| Concentration | n/a |
| Applications | ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Bin |
| Immunogen | Immunogen: Recombinant human Apoptosis-inducing factor 1, mitochondrial protein(103-612aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9417 / sc-9416 / sc-5586 |
| Other Names | [Programmed cell death protein 8; AIFM1; AIF; PDCD8], [AIFM1; AIFM1; AIF; CMT2D; CMTX4; COWCK; NADMR; NAMSD; PDCD8; COXPD6; AIF; PDCD8] |
| Gene, Accession # | Gene ID: 9131, NCBI: NP_001124318.2, UniProt: O95831 |
| Catalog # | MBS1493729 |
| Price | $160, $235 |
| Order / More Info | Human Apoptosis-inducing factor 1, mitochondrial Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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