DEDD Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | DEDD |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: DEDD antibody detects endogenous levels of total DEDD. Function: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity).Subunit Structure: Interacts with CASP8, CASP10, KRT8, KRT18, CASP3 and FADD. Homodimerizes and heterodimerizes with DEDD2.Post-translational Modifications: Exists predominantly in a mono-or diubiquitinated form. |
| Immunogen | Immunogen: A synthesized peptide derived from human DEDD Subcellular Location: Cytoplasm. Nucleus > Nucleolus. Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli (By similarity). Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells. Tissue Specificity: Widely expressed with highest levels in testis. < |
| Other Names | [CASP8IP1; Death effector domain containing; Death effector domain containing protein; Death effector domain containing testicular molecule; Death effector domain-containing protein; Death effector domain-containing testicular molecule; DEDD 1; dedD; DEDD_HUMAN; DEDD1; DEDPro 1; DEDPro1; DEFT; FLDED 1; FLDED-1; FLDED1; KE 05; KE05; OTTHUMP00000031822] |
| Gene, Accession # | [DEDD], Gene ID: 9191, NCBI: NP_001034800.1, UniProt: O75618 |
| Catalog # | MBS9602959 |
| Price | $240, $280 |
| Order / More Info | DEDD Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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