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Antigenic Specificity | Phospho-Mouse TSC2 (S1412) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.3 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1412 of mouse TSC2. In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mech |
Immunogen | n/a |
Other Names | [Tuberin; Tuberous sclerosis 2 protein homolog; Tsc2] |
Gene, Accession # | [Tsc2], NCBI: Q61037.1, UniProt: Q61037 |
Catalog # | MBS9203851 |
Price | $165, $370 |
Order / More Info | Phospho-Mouse TSC2 (S1412) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |