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Antigenic Specificity | Inducible Nitric Oxide Synthase |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA, Western Blot |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects a 130 kDa* protein on SDS-PAGE immunoblots of mouse macrophages treated with IFNg and LPS. Nitric oxide (NO) has a broad range of biological activities and is implicated in signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOS), the enzymes responsible for synthesis of NO, are homodimers whose monomers are themselves two fused enzymes: a cytochrome reductase and a cytochrome that requires three cosubstrates (L-arginine, NADPH, and O2) and five cofactors or prosthetic groups(FAD, FMN, calmodulin, tetrahydrobiopterin, and heme). Several distinct NOS isoforms are produced from three distinct genes. These include twoconstitutive Ca2+/CaM-dependent forms of NOS: nNOS (also designated bNOS, NOS |
Immunogen | Immunogen: Amino acid residues within the C-terminal region of human iNOS. The human iNOS sequence used has high homology with similar regions inrat and mouse iNOS. |
Other Names | [iNOS; NOS type II; Inducible nitric oxide synthase; Hepatocyte NOS], [iNOS; Nos2] |
Gene, Accession # | NCBI: AAC83553.1, UniProt: Q06518 |
Catalog # | MBS472029 |
Price | $325 |
Order / More Info | Inducible Nitric Oxide Synthase Antibody from MYBIOSOURCE INC. |
Product Specific References | • Kleinert, H. et al. (2003) Biol Chem. 384(10-11):1343.• Xie, Q.W. et al. (1992) Science 256:225. |