Edit |   |
---|---|
Antigenic Specificity | Apaf-1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Apaf-1 Polyclonal Antibody detects endogenous levels of Apaf-1 protein. APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. |
Immunogen | Immunogen: Synthesized peptide derived from the internal region of human Apaf-1 |
Other Names | [Rabbit Apaf-1; APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1] |
Gene, Accession # | [Apaf-1], Gene ID: 317, NCBI: NP_001151.1, UniProt: O14727 |
Catalog # | MBS9703765 |
Price | $130, $220, $325 |
Order / More Info | Apaf-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |