Rat p75NTR Neurotrophin Receptor Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityRat p75NTR Neurotrophin Receptor
Clonemonoclonal
Host SpeciesMouse
Reactive Speciesrat
IsotypeIgG1
FormatProtein G purified
Size0.05 mL
Concentration1ug/ul
ApplicationsWestern Blot (WB), Immunohistochemistry (IHC)
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DescriptionSpecificity: 192-IgG reacts with rat p75. It does not cross-react with p75 of human or mouse origin. p75NTR known as a cell surface receptor for NGF, BDNF, NT-3 and NT-4, is also a receptor for b-amyloid, and for the myelin axon repellant protein MAG.1, 2, 4, 6 Binding of neurotrophins induces receptor dimerization followed by phosphorylation of receptor kinase residues and recruitment of intracellular proteins involved in signal transduction. p75NTR functions alone, or in functional complexes with the neurotrophin receptors trkA, trkB and trkC. p75NTR signals via interaction with different transducers such as TRAF6, IRAK, and RIP-2, activating NF-kappaB, JNK and p38, and inactivating rhoA.1, 3, 6 Receptor degradation is mediated by a metal
ImmunogenImmunogen: Solubilized proteins from PC12 membranes.
Other Namesn/a
Gene, Accession #[NTR]
Catalog #MBS4157670
Price$725
Order / More InfoRat p75NTR Neurotrophin Receptor Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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